Ceruloplasmin – examination, standards, preparation

Ceruloplasmin is a protein present in blood serum that plays an important role in the human body. It is a key marker in the diagnosis of many diseases, especially those related to copper metabolism. In the following article, we will discuss what ceruloplasmin is, when to test for ceruloplasmin levels, the causes of elevated and decreased ceruloplasmin, how to prepare for the test, and how much a ceruloplasmin test costs. You will also learn where to find more information on this topic.

What is ceruloplasmin?

Ceruloplasmin is a protein that plays an important role in the body. Its main role is to transport copper, which is necessary for many biochemical processes. Ceruloplasmin also helps regulate copper levels in the blood, preventing it from accumulating excessively in the body. Moreover, it takes part in the process of defense against free radicals, which makes it an important element of the immune system.

When should ceruloplasmin levels be tested?

Ceruloplasmin level testing may be recommended in a variety of situations. The main indications for this test are:

• Diagnostics of Wilson-Konovalov diseases – a rare genetic disease that leads to copper metabolism disorders.
• Misdiagnosis of liver diseases – ceruloplasmin testing can help exclude or confirm various liver diseases.
• Treatment monitoring – patients diagnosed with Wilson-Konovalov disease are often subjected to treatment, and ceruloplasmin levels can be assessed to assess the effectiveness of the therapy.
• Diagnostics of inflammation and cancer – ceruloplasmin is an acute phase protein that can increase in response to inflammation or the presence of cancer.

Elevated ceruloplasmin – causes and symptoms

An increase in ceruloplasmin levels may be associated with a variety of diseases and conditions. The main causes of elevated ceruloplasmin are:

• Wilson-Konovalov disease – a genetic disease leading to copper metabolism disorders.
• Liver diseases – e.g. cirrhosis, hepatitis.
• Inflammation – Ceruloplasmin can increase as a result of infection or inflammation.
• Cancers – Some cancers can cause an increase in ceruloplasmin levels.

Symptoms of elevated ceruloplasmin may be nonspecific and depend on the cause. They may include fatigue, nausea, abdominal pain and neurological disorders in patients with Wilson-Konovalov disease.

Reduced ceruloplasmin level – causes and symptoms

Decreased ceruloplasmin levels are less common than elevated levels, but may also be associated with various diseases. The main causes of decreased ceruloplasmin are:

• Liver diseases – e.g. liver cirrhosis.
• Copper deficiency – may occur as a result of poor absorption of copper from food or its insufficient amount in the diet.
• Genetic diseases – Some rare genetic diseases can lead to reduced levels of ceruloplasmin.

Symptoms of decreased ceruloplasmin are usually related to copper deficiency and may include weakness, joint and muscle pain, and neurological disorders.

Ceruloplasmin test – price/reimbursement and referral

Ceruloplasmin levels are tested using a blood sample taken from a vein. The price of this test may vary and depends on the laboratory and region of the country. Some facilities offer ceruloplasmin testing under the National Health Fund, provided you have a referral from a specialist. It is worth consulting a doctor to obtain a referral and information about costs.

Your suggestions

If you suspect that your ceruloplasmin levels may be abnormal or if you have symptoms that suggest problems with copper metabolism, consult your doctor immediately. Only he can order appropriate tests and make a diagnosis.

Recommended articles

If you want to learn more about ceruloplasmin and the issue related to it, we recommend that you read the following articles:

• “Wilson-Konovalov disease – symptoms, treatment, diagnosis”
• “Copper in the diet – why is it important and how to provide it?”
• “Blood test – what are the most important blood tests and when should they be performed?”

It is important to be well-informed about ceruloplasmin and related health so that you can take care of yourself and your loved ones.